Indication:
Larogen capsules, containing 25mg of Larotrectinib, are prescribed for treating solid tumors characterized by neurotrophic receptor tyrosine kinase (NTRK) gene fusions.

Pharmacology:
Larotrectinib functions as a targeted therapy by acting as a tyrosine kinase inhibitor. It targets specific enzymes pivotal in the proliferation of cancer cells, particularly those exhibiting NTRK gene fusions. Larotrectinib’s mechanism entails blocking these enzymes, thereby impeding tumor growth and advancement.

Dosage and Administration:
The prescribed dosage of Larogen capsules is usually taken orally, following healthcare provider instructions. Dosage specifics may vary based on patient factors like weight, overall health status, and the type and severity of the cancer being addressed.

Interaction:
Larotrectinib has the potential to interact with various medications, including other tyrosine kinase inhibitors and drugs metabolized by cytochrome P450 enzymes. Patients must inform their healthcare provider about all medications, supplements, and herbal products they are using to prevent potential interactions.

Side Effects:
Common adverse effects associated with Larogen capsules may include fatigue, nausea, vomiting, diarrhea, dizziness, and alterations in taste perception. However, more severe reactions like hepatotoxicity, cardiac toxicity, and allergic responses are also possible. Patients should promptly seek medical attention for any severe or persistent side effects.

Precautions and Warnings:
Patients undergoing treatment with Larogen capsules should undergo close monitoring for potential adverse reactions, particularly through liver function tests and cardiac monitoring. The use of Larotrectinib during pregnancy may pose fetal harm, necessitating contraception for both males and females during treatment and for a specified period afterward. Breastfeeding is discouraged while taking Larogen capsules.

Overdose Effects:
In the event of Larogen capsule overdose, patients may experience intensified adverse effects such as nausea, vomiting, diarrhea, and dizziness. Management typically involves supportive care and monitoring for complications. Immediate medical attention is recommended if overdose is suspected.