Indication:
Niragen, comprising Niraparib at a concentration of 100mg per capsule, is approved for the management of specific cancer types, notably ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. Typically, it’s prescribed as maintenance therapy for patients showing a positive response to platinum-based chemotherapy.

Pharmacology:
Niraparib functions as a poly(ADP-ribose) polymerase (PARP) inhibitor. It disrupts DNA repair mechanisms within cancer cells, leading to their demise. By specifically inhibiting PARP enzymes responsible for DNA repair, Niraparib obstructs cancer cells’ ability to mend chemotherapy-induced DNA damage, ultimately resulting in cell death.

Dosage and Administration:
Niragen is usually administered orally once daily, with or without food. The prescribed dosage varies depending on individual patient characteristics such as weight, treatment tolerance, and cancer type. Adjustments or interruptions in dosage might be necessary depending on the occurrence of adverse reactions.

Interaction:
Niragen may interact with various medications, including other chemotherapy drugs, compounds impacting liver function, and those prolonging the QT interval. Patients should disclose all medications, supplements, and herbal products to their healthcare provider to mitigate potential interactions.

Side Effects:
Common side effects of Niragen encompass nausea, fatigue, vomiting, reduced appetite, and diarrhea. However, more severe effects like bone marrow suppression leading to decreased blood cell counts, hypertension, and gastrointestinal perforation may also arise. Patients should promptly seek medical attention for severe or persistent adverse effects.

Precautions and Warnings:
Patients undergoing Niragen treatment should undergo regular monitoring of blood cell counts, liver function, and blood pressure. Usage of Niraparib during pregnancy may result in fetal harm, necessitating contraception for both genders during treatment and for a specified period afterward. Breastfeeding is not recommended while taking Niragen.

Overdose Effects:
In instances of Niragen overdose, patients may experience intensified adverse effects such as bone marrow suppression and gastrointestinal symptoms. Management typically involves supportive care and monitoring for complications. Immediate medical attention is crucial if overdose is suspected.