Indication:
AVALET-20 tablets, containing 20mg of Avatrombopag, are indicated for the treatment of thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure.

Pharmacology:
Avatrombopag, the active ingredient in AVALET-20 tablets, acts as a thrombopoietin receptor agonist. It stimulates the production of platelets in the bone marrow by binding to and activating the thrombopoietin receptor. This mechanism leads to increased platelet production and elevation of platelet counts in the bloodstream, thereby reducing the risk of bleeding in patients with chronic liver disease.

Dosage and Administration:
The recommended dosage of AVALET-20 tablets is typically administered orally once daily for 5 consecutive days before the scheduled procedure. The tablets should be taken on an empty stomach at least 2 hours before or 4 hours after any food or dairy products. Dosage adjustments may be necessary based on individual patient factors, such as platelet counts and response to treatment.

Interaction:
Avatrombopag may interact with certain medications, including anticoagulants and drugs that affect liver function. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions.

Side Effects:
Common side effects of AVALET-20 tablets may include headache, fatigue, nausea, diarrhea, and upper respiratory tract infection. More serious side effects such as thromboembolism and hepatotoxicity may occur. Patients should seek medical attention if they experience any severe or persistent side effects.

Precautions and Warnings:
Patients receiving treatment with AVALET-20 tablets should be monitored for potential adverse reactions, including changes in liver function tests and signs of thromboembolism. Avatrombopag may increase the risk of thromboembolic events, and caution should be exercised in patients with a history of thromboembolism. It is important to discuss the risks and benefits of treatment with AVALET-20 tablets with the healthcare provider.

Overdose Effects:
In cases of overdose with AVALET-20 tablets, patients may experience an increased risk of adverse effects such as thromboembolism and hepatotoxicity. Management of overdose typically involves supportive care and monitoring for complications. Immediate medical attention is advised if overdose is suspected.