Azithromax (Azithromicin) 500 mg

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Azithromax is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in skin and soft tissue infections. In sexually transmitted diseases in men and women, Azithromax is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.

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    Indications of Azithromax 500 mg

    Azithromax 500 mg is prescribed for infections (produced by susceptible organisms) in the upper respiratory tract, including sinusitis and pharyngitis/tonsillitis, the lower respiratory tract, including bronchitis and pneumonia, the otitis media, and the skin and soft tissue. Azithromax 500 mg is recommended for the treatment of non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis in sexually transmitted illnesses in both men and women.

    Theropeutic Class

    Macrolides

    Pharmacology

    Azithromax 500 mg belongs to the macrolide subclass of antibiotics known as azalide. In order to prevent microbial protein synthesis, Azithromax 500 mg binds to the 50s ribosomal subunit of susceptible species. Moraxella catarrhalis, anaerobes such as Bacteroides fragilis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, and Neisseria gonorrhoeae, as well as gram-positive and gram-negative bacteria such as Staphylococcus aureus, Streptoc Moreover, in vitro testing of Azithromax 500 mg shown action against Campylobacter sp., Toxoplasma gondii, Treponema pallidum, Mycoplasma pneumoniae, Legionella pneumophila, and hominins.

    Dosage of Azithromax 500 mg

    Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given. Children: 10 mg/kg body weight once daily for 3 days for child over 6 months 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg. In typhoid fever, 500 mg (21/2 teaspoonfuls) once daily for 7-10 days is given.

    Administration of Azithromax 500 mg

    Procedure for reinstatement after suspension- Step 1: Thoroughly shake the bottle to break up the powder. Step 2: Fill the bottle with boiled and cooled water to the watermark on the label. Step 3: Mix the powder and water thoroughly to combine. Take Azithromax 500 mg at least one hour before or two hours after eating.

    Interaction of Azithromax 500 mg

    When food and antacids are present, Azithromax 500 mg absorption is lessened. Due to the potential for ergotism brought on by an interaction between Azithromax 500 mg and the cytochrome P-450 system, Azithromax 500 mg should be avoided in patients who are receiving ergot alkaloids. With co-administration, care should be taken since macrolides raise the plasma levels of cyclosporin and digoxin. Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine have not been found to interact with Azithromax 500 mg.

    Contraindications

    Those who are hypersensitive to Azithromax 500 mg or any other macrolide antibiotic should not take Azithromax 500 mg. Ergot derivatives and Azithromax 500 mg should not be administered together. Those with liver disorders should not use Azithromax 500 mg.

    Side Effects of Azithromax 500 mg

    Low-frequency side effects are experienced after taking Azithromax 500 mg. A therapeutic withdrawal will reverse the adverse effects, which include nausea, vomiting, abdominal pain or cramps, flatulence, diarrhea, headaches, and skin rashes.

    Pregnancy & Lactation

    The Azithromax 500 mg pregnancy category is B. Studies on animal reproduction have shown that Azithromax 500 mg has no evidence of harming the fetus. Pregnant women have not been the subject of any good, controlled studies. Azithromax 500 mg should only be used during pregnancy if no other suitable options are available, as research on animal reproduction are not always indicative of human response. The presence of Azithromax 500 mg in breast milk is unknown. Hence, when giving Azithromax 500 mg to nursing mothers, care should be taken.

    Precautions & Warnings

    It is advised to keep an eye out for any indications of superinfection with non-susceptible organisms, such as fungus when using any antibiotic. Those with renal impairment don’t require a dose adjustment.

    Overdose Effects of Azithromax 500 mg

    There is no information on Azithromax 500 mg overdosage. Macrolide antibiotic overdose symptoms can include hearing loss, extreme nausea, vomiting, and diarrhea. The use of gastric lavage and other supportive treatments is advised.

    Storage Conditions

    Keep dry and away from heat and light. Keep out of children’s reach.
    Generic Name:

    Azithromycin

    Theraputic Category:

    Antibiotic

    Pack Size:

    500mg : 2×5's, 200 mg/5 ml : 15 ml, 200 mg/5 ml : 35 ml, 200 mg/5 ml : 50 ml

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