Neratinib 40 mg tablet for HER2-positive breast cancer treatment
Neratinib 40 mg is an oral targeted anti-cancer medicine used in the treatment of HER2-positive breast cancer. It belongs to the class of tyrosine kinase inhibitors (TKIs) and is commonly prescribed as extended adjuvant therapy to reduce the risk of cancer recurrence.
🔬 Generic Information
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Generic Name: Neratinib
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Strength: 40 mg
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Dosage Form: Film-Coated Tablet
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Category: Oncology / Anti-Cancer Medicine
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Therapeutic Class: Tyrosine Kinase Inhibitor (TKI)
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Drug Class: HER2 Tyrosine Kinase Inhibitor
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Route of Administration: Oral
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Prescription Status: Prescription Only
🧬 Mechanism of Action
Neratinib works by irreversibly inhibiting HER2 and EGFR receptors, which play a key role in the growth and spread of HER2-positive cancer cells. By blocking these pathways, Neratinib helps slow tumor growth and reduce recurrence risk.
💊 Uses of Neratinib
Neratinib is used in:
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HER2-positive breast cancer
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Extended adjuvant treatment after trastuzumab therapy
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Early-stage and advanced breast cancer (as prescribed)
🕒 Dosage & Administration
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Dosage is determined by an oncologist
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Typically taken once daily
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Should be taken with food
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Tablets should be swallowed whole with water
⚠️ Always follow the doctor’s prescription and treatment protocol.
⚠️ Possible Side Effects
Common side effects include:
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Diarrhea
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Nausea
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Fatigue
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Abdominal pain
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Loss of appetite
Serious side effects may include:
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Liver enzyme elevation
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Severe diarrhea if not managed properly
👉 Immediate medical attention is required if severe symptoms occur.
🚫 Precautions & Warnings
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Not recommended during pregnancy or breastfeeding
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Liver function monitoring required
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Adequate diarrhea management is essential
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Inform your doctor about all current medications
🔄 Drug Interactions
Neratinib may interact with:
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Proton pump inhibitors (PPIs)
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CYP3A4 inhibitors or inducers
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Certain antifungal and antibiotic medicines
Always consult a healthcare professional before combining medications.
📦 Storage Instructions
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Store below 30°C
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Protect from moisture and light
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Keep out of reach of children
🌍 International Market Information
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Prescription-only oncology medicine
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Suitable for regulated and semi-regulated markets
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Export subject to destination country regulations
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Labeling and documentation as per manufacturer and importer requirements
