Indications of Tibsovo (Ivosenib) – Ivosidenib 250mg
Tibsovo (Ivosenib) – Ivosidenib 250mg is approved for:
Acute Myeloid Leukemia (AML)
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Newly diagnosed IDH1-mutated AML in adults ineligible for intensive chemotherapy
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Relapsed or refractory IDH1-mutated AML
Cholangiocarcinoma
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Advanced or metastatic IDH1-mutated bile duct cancer
Other IDH1-Mutated Tumors
As recommended by an oncologist.
Mutation Confirmation Required
Treatment should begin only after IDH1 mutation is verified through a validated test.
Pharmacology of Tibsovo (Ivosenib) – Ivosidenib 250mg
Tibsovo (Ivosenib) – Ivosidenib 250mg works by selectively inhibiting the mutant IDH1 enzyme.
Mechanism
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Mutant IDH1 overproduces 2-hydroxyglutarate (2-HG)
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Elevated 2-HG blocks normal cell differentiation
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The drug reduces 2-HG, restoring proper maturation of cancer cells
Effect
This slows cancer progression while minimizing impact on healthy cells.
Dosage & Administration of Tibsovo (Ivosenib) – Ivosidenib 250mg
Recommended Dose
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250 mg once daily
Administration Instructions of Tibsovo (Ivosenib) – Ivosidenib 250mg
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Swallow whole
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Take with or without food
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Avoid high-fat meals
Monitoring
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ECG for QT interval
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Liver function tests
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Complete blood count
Dose Adjustment
Adjust only under oncologist supervision.
Interactions
Use Caution With:
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Strong CYP3A4 inhibitors or inducers
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QT-prolonging medications
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CYP3A4 substrates
Food Interaction
High-fat meals may increase drug exposure.
Contraindications
Do Not Use In:
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Hypersensitivity to Tibsovo (Ivosenib) – Ivosidenib 250mg
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Uncontrolled QT prolongation
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Concomitant strong CYP3A4 inducer therapy
Side Effects of Tibsovo (Ivosenib) – Ivosidenib 250mg
Common
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Fatigue
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Nausea, vomiting
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Diarrhea or constipation
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Muscle or joint pain
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Elevated liver enzymes
Serious
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Differentiation syndrome
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QT interval prolongation
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Tumor lysis syndrome
Emergency Signs
Fever, rapid weight gain, breathing difficulty.
Pregnancy & Lactation
Pregnancy
Tibsovo (Ivosenib) – Ivosidenib 250mg can harm the fetus; avoid use.
Lactation
Breastfeeding is not recommended.
Contraception
Both men and women should use effective contraception during treatment and after completion.
Precautions & Warnings
Risk Monitoring
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ECG at baseline and during therapy
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Liver function monitoring
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Regular blood counts
Differentiation Syndrome
Can occur anytime; requires prompt treatment.
Patients With Hepatic Impairment
Use only with caution.
Overdose
Possible Symptoms
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Severe nausea
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QT prolongation
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Liver enzyme abnormalities
Management
Supportive care and immediate medical attention.
Therapeutic Class
IDH1 Inhibitor / Targeted AML & Cholangiocarcinoma Therapy
Storage Conditions
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Store below 30°C
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Keep in original packaging
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Protect from heat, moisture, and sunlight
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Keep away from children
FAQ
What is Tibsovo (Ivosenib) – Ivosidenib 250mg used for?
For IDH1-mutated AML and cholangiocarcinoma.
Is Ivosenib the same as Ivosidenib?
Yes — Ivosenib is Everest Pharma’s brand containing Ivosidenib 250mg.
Do you ship worldwide?
Yes, Oncology Medicine Pharmacy provides secure global shipping.
Do I need a prescription?
Yes, a valid prescription is required.
Can I take it with food?
Yes, but avoid high-fat meals.
