Xeljanz XR Tofacitinib 11 mg – Once-Daily Extended-Release JAK Inhibitor
Xeljanz XR Tofacitinib 11 mg is a once-daily, extended-release formulation designed for patients with moderately to severely active rheumatoid arthritis and other autoimmune inflammatory conditions. As a powerful JAK inhibitor, this medication helps reduce joint pain, swelling, morning stiffness, and prevents long-term structural joint damage. It is widely prescribed across global markets as a convenient oral alternative to injectable biologic therapies.
What Is Xeljanz XR Tofacitinib 11 mg?
Xeljanz XR is the extended-release version of Tofacitinib, offering 24-hour coverage with just one tablet per day. It provides steady JAK1 and JAK3 inhibition, ensuring consistent immune modulation throughout the day.
The extended-release mechanism makes it suitable for patients who prefer simple, once-daily dosing with stable blood concentration.
How Xeljanz XR Tofacitinib 11 mg Works
Tofacitinib selectively blocks Janus kinase (JAK1/JAK3) pathways that regulate immune cell activity. By reducing inflammatory signaling, it:
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Decreases joint inflammation
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Reduces pain and stiffness
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Slows disease progression
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Improves mobility and quality of life
This mechanism makes it valuable not only for rheumatoid arthritis but also other autoimmune disorders.
Medical Uses of Xeljanz XR Tofacitinib 11 mg
1. Rheumatoid Arthritis (Primary Use)
Indicated for adults with moderately to severely active RA who did not respond adequately to methotrexate.
2. Psoriatic Arthritis
Helps reduce inflammation, swelling, and plaque-related symptoms.
3. Ulcerative Colitis (Specialist-directed)
Extended-release dosing may be used depending on treatment plan.
4. Off-Label Uses (Global Market)
Although not approved in all regions, physicians sometimes use Tofacitinib for:
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Alopecia areata
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Vitiligo
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Severe psoriasis
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Other autoimmune skin diseases
Benefits of Xeljanz XR Tofacitinib 11 mg
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✔ Once-daily dosing — simple & convenient
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✔ Extended-release action for 24-hour inflammation control
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✔ Oral tablet — no injections required
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✔ Rapid symptom improvement in many patients
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✔ Suitable for long-term RA management
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✔ Can be used alone or with non-biologic DMARDs
Dosage & Administration
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Standard adult dose: One Xeljanz XR 11 mg tablet once daily
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Swallow whole, do not crush
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May be taken with or without food
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Dose adjustments may be needed in renal/hepatic impairment
Side Effects
Common:
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Headache
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Nasopharyngitis
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Increased cholesterol
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Stomach upset
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High blood pressure
Serious (Less Common):
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Severe infections
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Blood clots
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Heart-related risks
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Liver enzyme elevation
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Lowered white blood cell count
Seek medical attention if breathing problems, chest pain, fever, or unusual bruising occur.
Warnings & Precautions
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Screen for TB and hepatitis before therapy
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Avoid live vaccines during treatment
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Regular monitoring of CBC, liver enzymes, lipids
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Use in pregnancy/breastfeeding only if medically necessary
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Not to be combined with biologic DMARDs
Storage Information
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Store at 20–30°C
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Protect from moisture and sunlight
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Keep out of children’s reach
